This week: Bricks & Barley Irish-Style Dry Stout
Stevens Point Brewing Co., Stevens Point, Wis.
www.copps.com/bricksandbarley.aspx
Bricks and Barley is the name Roundy's Supermarkets uses for its house-brand beers to supply its Wisconsin-based Copps and Pick 'n Save grocery stores. It contracts with the Stevens Point brewery to produce the beers. Roundy's also operates Rainbow Foods in Minnesota and Mariano's Fresh Market in Illinois.
The B&B stout started out as a passable attempt at the style. It had the flavor profile consisting of chocolate, coffee and roasted barley notes. It drank and finished very dry, with the dryness lingering for several minutes after tasting.
Hot Supermarket Companies To Watch For 2015: S&W Seed Company(SANW)
S&W Seed Company engages in contracting the production of alfalfa seed varieties, processing the seeds, and marketing the certified seed to agribusiness firms and farmers worldwide. It also involves in the production of stevia leaf. The company primarily offers high fall dormancy (FD) alfalfa seed varieties, as well as markets and sells other varieties, including FD 7, 6, and 4 varieties. It sells the seed primarily to dealers and distributors who, in turn, sell primarily to hay and dairy farmers who grow hay for dairy cattle and other livestock; and through brokers. The company was founded in 1980 and is headquartered in Five Points, California.
Advisors' Opinion:- [By Glenwoods]
�PureCircle does not grow its own product, but is more of a holding company as it contracts farms scattered around the globe to grow stevia to certain specifications.� One such farm is the S&W SEED Co. (NASDAQ:SANW).� Toward the end of 2011, PureCircle, with a goal of developing stevia in the U.S. for the U.S market, entered into a five-year agreementwith the California-based grower of high-yield alfalfa seeds, to grow stevia to the company�� specifications.� Unfortunately the results have not matched expectationsas reported by S&W Seed:
Hot Supermarket Companies To Watch For 2015: CDC Point SpA (CDC)
CDC Point SpA is an Italy-based company engaged in the information technology (IT) sector. The Company structures its business into two main sectors: Production and Distribution of IT, and Business Value-Added. Through the Production and Distribution of IT sector, it is active in the manufacture of consumer desktop personal computers, as well as in the distribution and retail of computer hardware; peripheral equipment and accessories, such as keyboards, monitors, webcams, card readers, audio systems, voice over Internet protocol (VoIP) accessories and routers, and software products. Through the Business Value-Added sector, it provides value added services and solutions, including voice over Internet protocol (VoIP) services; video surveillance and home automation technologies; software management and e-commerce solutions, and Web services, such as domain registering, hosting, server, email, positioning on search engines and Web marketing services. Advisors' Opinion:- [By abirk]
The people of America are becoming more and more health conscious as obesity is growing at a great pace. As per the Centers for Disease Control and Prevention (CDC), more than one third of US adults (35.7%) is obese. This point out the finger towards the fast-food industry as they are using trans fats (responsible for clogging arteries) in their products to make it more mouth watering.
Best Food Stocks To Watch Right Now: Westfield Group (WEFIF)
Westfield Group is engaged in ownership, development, design, construction, funds/asset management, leasing and marketing activities undertaken with respect to its global portfolio of retail properties. Property investments segment includes net property income from existing shopping centers and completed developments, revaluation of existing centers and other operational expenses. Property and project management segment includes income from third parties, property management and development fees, and associated business expenses. The development segment includes revaluation of redevelopments and development projects. The corporate business unit includes unallocated corporate entity expenses. In November 2013, Starwood Capital Group LLC acquired a majority interest in seven regional malls in the United States from the Westfield Group. Advisors' Opinion:- [By MARKETWATCH]
LOS ANGELES (MarketWatch) -- Australia stocks tilted lower early Monday as the Sydney markets reacted to last week's disappointing jobs numbers out of the U.S., with the S&P/ASX 200 (AU:XJO) down 0.2% at 5,304.40. Data out Friday showed the U.S. added a net 74,000 jobs, trailing a forecast for 193,000 positions, and while Wall Street ended mixed following the numbers, Australian stocks will global exposure moved lower. Financial major Macquarie Group Ltd. (AU:MQG) (MCQEF) fell 1.8%, mall developer Westfield Group Australia (AU:WDC) (WEFIF) retreated 0.6%, and media firm News Corp. (AU:NWS) (NWS) -- the parent of MarketWatch, publisher of this report -- gave up 1.3%. But the jobs report also depressed the U.S. dollar, which helped boost prices for dollar-denominated commodities, and this in turn supported Australian resource shares. BHP Billiton Ltd. (AU:BHP) (BHP) gained 0.6%, Rio Tinto Ltd. (AU:RIO) (RIO) added 0.9%, Alumina Ltd. (AU:AWC) (AWCMF) rallied 4.5%, and Fortescue Metals Group Ltd. (AU:FMG) (FSUMF) improved by 1.2%. A strong showing for Comex gold on Friday also sent Newcrest Mining Ltd.
- [By MARKETWATCH]
LOS ANGELES (MarketWatch) -- Australian stocks fell early Wednesday, tracking a weak lead from the U.S. but with a few blue-chip miners higher after gains for some commodities overnight. The S&P/ASX 200 (AU:XJO) retreated 0.4% to 5,237.80 after similar losses for the main Wall Street indexes, with the Australian benchmark trading around its lowest level since October. Among the major decliners, Qantas Airways Ltd. (AU:QAN) (QUBSF) lost 2.5%, Harvey Norman Holdings Ltd. (AU:HVN) (HNORY) gave up 1.3%, and Incitec Pivot Ltd. (AU:IPL) (ICPVY) fell 1.8%. Santos Ltd. (AU:STO) (STOSF) fell 2.6% on indication it will miss its lowered production guidance for 2013, according to the Australian Financial Review. On the upside, top miners BHP Billiton Ltd. (AU:BHP) (BHP) and Rio Tinto Ltd. (AU:RIO) (RIO) rose 0.3% and 0.7%, respectively, while Fortescue Metals Group Ltd. (AU:FMG) (FSUMF) traded 1% higher. Shares of global shopping-mall developer Westfield Group Australia (AU:WDC) (WEFIF) were on halt
Hot Supermarket Companies To Watch For 2015: Stericycle Inc (SRCL)
Stericycle, Inc., incorporated on March 21, 1989, is in the business of managing regulated waste and providing an array of related and complementary services. The Company operates in the United States, Argentina, Brazil, Canada, Chile, Ireland, Japan, Mexico, Portugal, Romania, Spain, and the United Kingdom. The regulated waste services the Company provides include medical waste disposal, its Steri-Safe medical waste and compliance program, its Clinical Services program, its Bio Systems reusable sharps disposal management services, pharmaceutical waste disposal, and hazardous waste disposal. In addition to the Company's regulated waste services, the Company offers regulated recall and returns management services, patient communication services, and medical safety products. The Company's regulated recall and returns management services consist of a number of solutions for a variety of businesses but consist primarily of managing the recall, withdrawal or return of expired or recalled products and pharmaceuticals. During the year ended December 31, 2012, it completed 41 acquisitions, of which 17 were domestic businesses and 24 were international businesses in Latin America, Europe, and Japan. In August 2013, Stericycle Inc acquired Eclipse Marketing.
The Company also provides communication services to healthcare providers to improve office productivity and communications with patients. As of December 31, 2012, the Company's worldwide networks included a total of 153 processing facilities, 141 transfer sites, and 64 recall and returns or communication services facilities. The Company serves approximately 541,000 customers worldwide, of which approximately 16,500 are large-quantity generators, such as hospitals, blood banks and pharmaceutical manufacturers, and approximately 524,500 are small-quantity generators, such as outpatient clinics, medical and dental offices, long-term and sub-acute care facilities, veterinary offices, municipalities and retail pharmacies. For large-quantity generat! ors of regulated waste such as hospitals and for pharmaceutical companies and distributors, the Company offers its regulated waste management services; its Bio Systems reusable sharps disposal management services; its pharmaceutical waste services; its Integrated Waste Stream Solutions (IWSS) program; a variety of products and services for infection control; its regulated recall and returns management services for expired or recalled products and pharmaceuticals, and variety of patient communication services. For small-quantity generators of regulated waste such as doctors' offices or retail pharmacies, the Company offers its Steri-Safe OSHA, HIPAA compliance, and clinical services programs.
The Company supplies specially designed reusable leak-resistant and puncture-resistant plastic containers to most of its large-quantity customers and many of its larger small-quantity customers. The Company collects containers or corrugated boxes of regulated waste from its customers depending upon customer requirements, contract terms and volume of waste generated. The waste is then transported directly to one of the Company's processing facilities or to one of its transfer stations where it is combined with other regulated waste and transported to a processing facility. The Company collects some expired or recalled products, but more typically, customer ships them directly to its processing facilities. Upon arrival at a processing facility, containers or boxes of regulated waste are typically scanned to verify that they do not contain any unacceptable substances like radioactive material. The regulated waste is then processed using one of the Company's various treatment or processing technologies. Upon completion of the particular process, the resulting waste or incinerator ash is transported for resource recovery, recycling or disposal in a landfill owned by an unaffiliated third party. The Company provides complete documentation to its customers for all regulated waste that the Company collect in ac! cordance ! with applicable regulations and customer requirements.
Advisors' Opinion:- [By Jason Moser]
I owe my love of investing to my father. And with that in mind, I give you the Father's Day Portfolio. These are 10 stocks that remind me of my dad, and together they will form a formidable, market-beating team that will offer investors outstanding returns for years to come.
Dick's Sporting Goods� (NYSE: DKS ) is a family affair. CEO Edward Stack is the son of founder Richard Stack, and he owns close to 18%�of the shares outstanding. I like what this company has done and where it's headed. It controls 8.5% of the tremendous sporting-goods market. Boston Beer� (NYSE: SAM ) �seems an appropriate call here. Having a beer with your dad is one of the great moments in life, and given that this company sold more than 50 beer varieties under the Samuel Adams brand in 2012, chances are pretty darn good that there may be a Sam Adams in Dad's fridge. My dad drives a�Ford� (NYSE: F ) Expedition, and he's owned a few other Fords in his life. Every time I see the blue oval I think of him, and I think this company will play a big part in the fast-changing automobile market.� I smile so wide it looks like I have a coat hanger in my mouth when I see my dad using his iPhone and iPad, courtesy of�Apple. The guy turned 71 this Father's Day (happy birthday, Dad!) and he's embraced technology like a 15-year-old. We all know that if you have a question these days you can just ask�Google. These guys do a lot of things well, but search and maps are their specialty. It's not just iDevices for my dad, either. He loves his new Kindle Paperwhite from Amazon.com, not to mention the fact that he can order just about anything from the e-commerce giant. My dad's a doctor, and�St. Jude Medical� (NYSE: STJ ) is a device company that has a wonderfully diverse product mix. From heart devices to strokes, Parkinson's, and migraines, �this company is playing a big role in up-and-coming medical technology. Shout-out No. 1 to our Ge
Hot Supermarket Companies To Watch For 2015: DUSA Pharmaceuticals Inc.(DUSA)
DUSA Pharmaceuticals, Inc., a vertically integrated dermatology company, develops and markets Levulan photodynamic therapy (PDT) and other products for common skin conditions primarily in the United States, Canada, and Korea. Its products include Levulan Kerastick 20% Topical Solution with PDT and the BLU-U brand light source for the treatment of non-hyperkeratotic actinic keratoses of the face or scalp. The company also markets the BLU-U without Levulan for the treatment of moderate inflammatory acne vulgaris and general dermatological conditions; and non-PDT drug products, such as ClindaReach and AVAR products. DUSA Pharmaceuticals, Inc. was founded in 1991 and is based in Wilmington, Massachusetts.
Advisors' Opinion:- [By CRWE]
DUSA Pharmaceuticals, Inc.(r) (Nasdaq:DUSA), a dermatology company that is developing and marketing Levulan(r) Photodynamic Therapy (PDT), reported that Bob Doman, President and Chief Executive Officer, will present a corporate overview at the Rodman & Renshaw 14th Annual Healthcare Conference on Monday, September 10, 2012 at 11:15 a.m. ET at The Waldorf Astoria Hotel in New York City.
Hot Supermarket Companies To Watch For 2015: UIL Holdings Corp (UIL)
UIL Holdings Corporation, incorporated on March 22, 1999, is engaged in the ownership of its operating regulated utility businesses. The utility businesses consist of the electric distribution and transmission operations of The United Illuminating Company (UI) and the natural gas transportation, distribution and sales operations of The Southern Connecticut Gas Company (SCG), Connecticut Natural Gas Corporation (CNG), and The Berkshire Gas Company (Berkshire, and together with SCG and CNG, the Gas Companies). The Company operates in Electric Distribution, Electric Transmission and Gas Distribution segments.
UI is an electric distribution and transmission utility. UI is also a party to a joint venture with certain affiliates of NRG Energy, Inc. (NRG affiliates) pursuant to which UI holds 50% of interests in GCE Holding LLC, whose wholly owned subsidiary, GenConn Energy LLC operates generation plants in Devon, Connecticut (GenConn Devon) and Middletown, Connecticut (GenConn Middletown).
Advisors' Opinion:- [By Jake L'Ecuyer]
Utilities sector gained 0.78 percent in the US market today. Among the utilities stocks, Huaneng Power International (NYSE: HNP) was down more than 1.4 percent, while UIL Holdings (NYSE: UIL) tumbled around 0.7 percent.
- [By Jake L'Ecuyer]
Utilities sector was the only decliner in the US market today. Top losers in the sector included UIL Holdings (NYSE: UIL), off 2.1 percent, and Crosstex Energy (NASDAQ: XTXI), down 2.2 percent.
- [By Jake L'Ecuyer]
Utilities sector was the only decliner in the US market today. Top losers in the sector included UIL Holdings (NYSE: UIL), off 2.1 percent, and Crosstex Energy (NASDAQ: XTXI), down 2.2 percent.
Hot Supermarket Companies To Watch For 2015: Marchex Inc.(MCHX)
Marchex, Inc. operates as a call advertising and small business marketing company. The company?s products, services, and technologies enable advertisers to reach consumers across mobile, online, and offline sources. It offers call advertising products and services to national advertisers, advertising agencies, and small advertiser reseller partners, which include pay-for-call through the Marchex Pay-For-Call Exchange and call analytics solutions comprising phone number and call tracking, call mining, keyword-level tracking, click-to-call, Website proxying, and other call-based products that enable customers to utilize mobile, online, and offline advertising. The company also offers small business marketing products that enable reseller partners of small business advertisers, such as Yellow Pages providers and vertical marketing service providers to sell call advertising and/or search marketing products through their existing sales channels, which are fulfilled across the c ompany?s distribution network, such as mobile sources, search engines, and traffic sources. In addition, it offers pay-per-click advertising to online users in response to their keyword search queries or on pages they visit throughout the company?s distribution network of search engines, shopping engines, third party verticals, local Websites, mobile distribution, and publishing network. Further, the company offers publishing network, which includes the company?s owned and operated Websites that help users to make decisions about the availability of local products and services. The Websites in the company?s publishing network include small business listings, as well as expert and user-generated reviews on small businesses. Marchex, Inc., through its products and services distributes advertisements from various advertisers and its reseller partners? advertisers. The company was founded in 2003 and is headquartered in Seattle, Washington.
Advisors' Opinion:- [By Seth Jayson]
Marchex (Nasdaq: MCHX ) reported earnings on May 8. Here are the numbers you need to know.
The 10-second takeaway
For the quarter ended March 31 (Q1), Marchex beat expectations on revenues and beat expectations on earnings per share.
Hot Supermarket Companies To Watch For 2015: Winmark Corporation(WINA)
Winmark Corporation operates as a franchisor of four retail store concepts that buy, sell, trade, and consign merchandise. The company franchises retail stores under the ?Plato?s Closet? name that sell and buy used clothing and accessories geared toward the teenage and young adult market; and under the ?Play It Again Sports? name, which sell, buy, trade, and consign used and new sporting goods, equipment, and accessories for various athletic activities, including hockey, wheeled sports, fitness, ski/snowboard, golf, and baseball/softball. It engages in franchising ?Once Upon A Child? branded retail stores that sell and buy used and new children?s clothing, toys, furniture, equipment, and accessories; and ?Music Go Round? branded retail stores that sell, buy, trade, and consign used and new musical instruments, speakers, amplifiers, music-related electronics, and related accessories for parents of children who play musical instruments, as well as for professional and amateur musicians. In addition, the company operates a middle-market equipment leasing business focusing on technology-based assets to serve large and medium-sized businesses; and a small-ticket financing business to serve small businesses. Further, it offers management services to Tomsten, Inc. As of September 24, 2011, the company had 923 franchises in operation. Winmark Corporation was founded in 1988 and is headquartered in Minneapolis, Minnesota.
Advisors' Opinion:- [By Seth Jayson]
Winmark (Nasdaq: WINA ) reported earnings on July 17. Here are the numbers you need to know.
The 10-second takeaway
For the quarter ended June 29 (Q2), Winmark beat slightly on revenues and beat expectations on earnings per share. - [By alicet236]
Chairman & CEO, 10% Owner of Winmark Corporation (WINA) John L. Morgan bought 2,000 shares on July 29, 2013 at an average price of $68.55. The total transaction amount was $137,100.
- [By Michael Lewis]
One of my favorite businesses, Winmark (NASDAQ: WINA ) , reported earnings this week. Earnings boosted 14% compared to the prior year's first quarter. Though the company continues to franchise its range of secondhand stores, the most compelling growth comes from the leasing division, which saw revenues jump by 30%. The company is underfollowed yet has been paying attractive special dividends while giving investors two-year capital appreciation of roughly 50%. As the company moves forward and pushes its leasing business to new heights, should you get in now?
- [By Seth Jayson]
Calling all cash flows
When you are trying to buy the market's best stocks, it's worth checking up on your companies' free cash flow once a quarter or so, to see whether it bears any relationship to the net income in the headlines. That's what we do with this series. Today, we're checking in on Winmark (Nasdaq: WINA ) , whose recent revenue and earnings are plotted below.
Hot Supermarket Companies To Watch For 2015: Shire PLC (SHPG)
Shire plc (Shire), incorporated on January 28, 2008, is a specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), gastrointestinal (GI) diseases, human genetic therapies (HGT) and regenerative medicine (RM), as well as opportunities in other therapeutic areas. As of December 31, 2012, the Company�� products included VYVANSE/VENVANSE (lisdexamfetamine dimesylate), ADDERALL XR (mixed salts of a single-entity amphetamine), INTUNIV (extended release guanfacine), EQUASYM (methylphenidate hydrochloride) modified release (XL), LIALDA (mesalamine)/ MEZAVANT(mesalazine), PENTASA (mesalamine), RESOLOR (prucalopride), FOSRENOL (lanthanum carbonate), XAGRID (anagrelide hydrochloride), REPLAGAL (agalsidase alfa), ELAPRASE (idursulfase), VPRIV (velaglucerase alfa), FIRAZYR (icatibant) and DERMAGRAFT(Human Fibroblast-Derived Dermal Substitute). As of December 31, 2012, the Company�� products under development included INTUNIV (extended release guanfacine), VYVANSE/VENVANSE (lisdexamfetamine dimesylate), INTUNIV, Guanfacine Carrier Wave, LIALDA (mesalamine)/MEZAVANT (mesalazine), RESOLOR (prucalopride), RESOLOR (prucalopride), SPD 557(M0003), XAGRID, VYVANSE (lisdexamfetamine dimesylate), REPLAGAL (agalsidase alfa), HGT-4510, HGT-2310, HGT-1410, HGT-1110, HGT-3010, and DERMAGRAFT. On January 31, 2012, the United States Food and Drug Administration approved VYVANSE for the maintenance treatment of ADHD in adults. In March 2013, it announced the acquisition Of Premacure AB. In January 2014, Shire Plc sold its DERMAGRAFT assets to Organogenesis Inc. In January 2014, Shire Plc acquired 79.5% interest in ViroPharma Inc.
VANSE/ VENVANSE
VYVANSE is a New Chemical Entity (NCE) and is the pro-drug stimulant for the treatment of ADHD, where the amino acid l-lysine is linked to d-amphetamine. VYVANSE is therapeutically inactive until metabolized in the body. The United Stat! es Food and Drug Administration approved VYVANSE as a once-daily treatment for children aged 6 to 12 with ADHD in February 2007, for adults in April 2008 and for adolescents aged 13 to 17 in November 2010. VYVANSE is available in the United States in six dosage strengths: 20 milligram, 30 milligram, 40 milligram, 50 milligram, 60 milligram and 70 milligram. Health Canada approved VYVANSE for the treatment of ADHD in pediatric patients aged 6 to 12 in February 2009, and for adolescents and adults in November 2010. In April 2012, ANVISA, the Brazilian health authority, granted marketing authorization approval for lisdexamfetamine dimesylate for the treatment of ADHD in children aged 6-12.
ADDERALL XR
ADDERALL XR is an extended release treatment for ADHD, which uses MICROTROL drug delivery technology and is designed to provide once-daily dosing. It is available in 5 milligram, 10 milligram, 15 milligram, 20 milligram, 25 milligram and 30 milligram capsules and can be administered either as a capsule or sprinkled on soft food. The United States Food and Drug Administration has approved ADDERALL XR as a once-daily treatment for children aged 6 to 12 with ADHD, for adults in and for adolescents aged 13 to 17. Teva Pharmaceutical Industries, Ltd. (Teva) and Impax Laboratories, Inc. (Impax) commenced commercial shipment of their authorized generic versions of ADDERALL XR in April and October 2009, respectively. Shire receives royalties from Impax�� sales of authorized generic ADDERALL XR.
INTUNIV
INTUNIV is a selective alpha-2A receptor agonist indicated for the treatment of ADHD. Alpha-2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signalling in the prefrontal cortex (Cell. 2007; 129:397-410). INTUNIV is non-scheduled and has no known potential for abuse or dependence. The United States Food and Drug Administration approved INTUNIV in September 2009, as a once-daily monotherapy treatment of ADHD in children and adolesce! nts aged ! 6 to 17. It is available in 1 milligram, 2 milligram, 3 milligram and 4 milligram tablets.
EQUASYM
Shire has acquired from UCB the worldwide rights (excluding the United States, Canada and Barbados) to EQUASYM (methylphenidate hydrochloride) IR and XL for the treatment of ADHD in children and adolescents aged 6 to 18. At December 31, 2012,EQUASYM XL was commercially available in 10 countries in 10mg, 20mg and 30mg strengths. EQUASYM XL is marketed in Mexico and South Korea under the trade name METADATE CD.
LIALDA/MEZAVANT
LIALDA is indicated for the induction ofmild to moderately active UC and for the maintenance of remission of UC. The addition of the indication for maintenance of remission of ulcerative colitis was approved by Health Canada in February 2011, and by the United States Food and Drug Administration in July 2011. LIALDA is once-daily oral formulation of mesalamine indicated for the induction and maintenance of remission. As of December 31, 2012, LIALDA/MEZAVANT (this product is marketed outside the United States as MEZAVANT) was commercially available in 19 countries either directly or through distributor arrangements.
PENTASA
PENTASA controlled release capsules are approved in the United States (marketed by Shire in the United States and by Ferring outside of the United States) and indicated for the induction of remission and for the treatment of patients with mild to moderately active ulcerative colitis. PENTASA is an ethylcellulose-coated, controlled release capsule formulation designed to release therapeutic quantities of mesalamine throughout the gastrointestinal tract. PENTASA is available in the United States in 250 milligram and 500 milligram capsules.
RESOLOR
RESOLOR (prucalopride), a 5-HT4 receptor agonists that stimulates gastrointestinal motility and acts primarily on different parts of the lower gastrointestinal tract (enterokinetic). In October 2009, RESOLOR was appr! oved by t! he EMA throughout the European Union as a once daily oral treatment for symptomatic treatment of chronic constipation in women in whom laxatives fail to provide adequate relief. In July 2010, Swissmedic granted RESOLOR marketing authorization in Switzerland for the treatment of idiopathic chronic constipation in adults. RESOLOR is available in milligram and 2 milligram dose strengths, both for once-daily dosing. At December 31, 2012, RESOLOR was available in six European Union countries. Formulated as a chewable tablet, FOSRENOL is available in 500 milligram, 750 milligram and 1,000 milligram dosage strengths.
XAGRID
XAGRID (anagrelide hydrochloride) is marketed in Europe for the reduction of elevated platelet counts in at-risk ET patients. XAGRID has been granted orphan drug status in the European Union. In the United States, anagrelide hydrochloride is sold by the Company under the name AGRYLIN for the treatment of thrombocythemia secondary to a MPD.
REPLAGAL
REPLAGAL is for the treatment of Fabry disease. Fabry disease is a genetic disorder resulting from a deficiency in the activity of the lysosomal enzyme alpha-galactosidase A, which is involved in the breakdown of fats. REPLAGAL is a human alpha-galactosidase A protein made in human cells that replaces the deficient alpha-galactosidase A with an active enzyme to ameliorate certain clinical manifestations of Fabry disease. At December 31, 2012, REPLAGAL was approved in 46 countries.
ELAPRASE
ELAPRASE is a treatment for Hunter syndrome (also known as Mucopolysaccharidosis Type II or MPS II). Hunter syndrome is a genetic disorder mainly affecting males that interferes with the body's ability to break down and recycle waste substances called mucopolysaccharides, also known as glycosaminoglycans (GAGs). ELAPRASE was approved by the United States Food and Drug Administration and granted marketing authorization by the EMA for the long term treatment of patients with Hunter ! syndrome.! ELAPRASE has been granted orphan drug by both the United States Food and Drug Administration and the EMA. ELAPRASE received approval from the Ministry of Health, Labour and Welfare in Japan. At December 31, 2012, ELAPRASE was approved in 51 countries.
VPRIV
VPRIV is a treatment for Type 1 Gaucher disease. Gaucher disease is an inherited genetic disorder, which results in a deficiency of the lysosomal enzyme beta-glucocerebrosidase. VPRIV was approved by the United States Food and Drug Administration in February 2010, for the long-term treatment of patients with Type 1 Gaucher disease. The EMA approved the marketing authorization for the use of VPRIV in August 2010. VPRIV was authorized as an orphan medicine through the Centralised Procedure in Europe. At December 31, 2012, VPRIV was approved in 38 countries.
FIRAZYR
FIRAZYR is a peptide-based therapeutic developed for the symptomatic treatment of acute attacks of HAE. In July 2008 the EMA granted marketing authorization throughout the European Union for the use of FIRAZYR for the symptomatic treatment of acute attacks of HAE, and in May 2011 approved FIRAZYR for self-administration after training in subcutaneous injection technique by a healthcare professional. In August 2011, the United States Food and Drug Administration granted marketing approval for FIRAZYR in the United States for treatment of acute attacks of HAE in adults aged 18 and older. After injection training, patients may self-administer FIRAZYR. FIRAZYR has been granted orphan drug by both the United States Food and Drug Administration and the EMA. At December 31, 2012, FIRAZYR was approved in 38 countries globally.
DERMAGRAFT
DERMAGRAFT is a bio-engineered skin substitute that assists in restoring damaged tissue. DERMAGRAFT is indicated for use in the treatment of full-thickness Diabetic foot ulcers (DFU) greater than six weeks in duration, which extend through the dermis, but without tendon, muscle, joint capsu! le, or bo! ne exposure. DERMAGRAFT is approved by the United States Food and Drug Administration as a Class III medical device for the treatment of DFUs. DERMAGRAFT is also approved for the treatment of DFUs in South Africa, Israel and Singapore.
The Company competes with Shionogi & Co., Ltd., Janssen-Cilag, Novartis, Medice, Eli Lilly, Warner Chilcott, Synergy Pharmaceuticals, Inc., ARYx Therapeutics, Theravance, Inc., Sucampo Pharmaceuticals, Inc., Albireo, Actelion Ltd., Protalix BioTherapeutics Inc, Genzyme, CSL Behring, Pharming Group N.V., ViroPharma, Dyax Corporation, Organogenesis, Healthpoint, Soluble System, KCI, Smith & Nephew, Aurobindo and Apotex.
Advisors' Opinion:- [By David Williamson and Alison Southwick]
In this segment from Monday's episode, health-care analyst David Williamson discusses Shire (NASDAQ: SHPG ) , a biopharmaceutical company focusing on rare diseases, that just beat out several rivals with its bid of $4.2 billion to acquire ViroPharma (NASDAQ: VPHM ) . ViroPharma sells the successful hereditary angioedema drug Cinryze, which is used in prophylactic treatment of the disease. Shire sees this as an immediately complementary fit with its drug Firazyr, which is for patients already suffering from the active disease.
- [By Max Macaluso and David Williamson]
At the end of last week, a Bloomberg article revealed that Shire (NASDAQ: SHPG ) and pharmaceutical giant Sanofi� (NYSE: SNY ) may be circling ViroPharma� (NASDAQ: VPHM ) . The the following video, from The Motley Fool's health care show Market Checkup, analysts David Williamson and Max Macaluso take a close look at ViroPharma and discuss the recent interest in this small biotech company.
- [By George Budwell]
Shire plc (NASDAQ: SHPG ) is in the process of buying orphan drug-specialist ViroPharma (NASDAQ: VPHM ) for $4.2 billion, strengthening Shire's already robust commercial drug portfolio for rare diseases. The deal is expected to be finalized no later than Jan. 9, after Shire extended its tender offer to acquire all outstanding ViroPharma shares last week.
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